Journal article
Phote-HrTH (Phormia terraenovae Hypertrehalosaemic Hormone), the Metabolic Hormone of the Fruit Fly: Solution Structure and Receptor Binding Model
IA Abdulganiyyu, MA Sani, F Separovic, H Marco, GE Jackson
Australian Journal of Chemistry | CSIRO PUBLISHING | Published : 2020
DOI: 10.1071/CH19461
Abstract
Fruit flies are a widely distributed pest insect that pose a significant threat to food security. Flight is essential for the dispersal of the adult flies to find new food sources and ideal breeding spots. The supply of metabolic fuel to power the flight muscles of insects is regulated by adipokinetic hormones (AKHs). The fruit fly, Drosophila melanogaster, has the same AKH that is present in the blowfly, Phormia terraenovae; this AKH has the code-name Phote-HrTH. Binding of the AKH to the extra-cellular binding site of a G protein-coupled receptor causes its activation. In this paper, the structure of Phote-HrTH in sodium dodecyl sulfate (SDS) micelle solution was determined using NMR restr..
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Awarded by Australian Research Council
Funding Acknowledgements
This project received funding from the National Research Foundation of South Africa (grant nos 93450 and 85466 to Graham E. Jackson) and the University of Cape Town Research Committee. The Centre for High-Performance Computing (CHPC), South Africa, provided computational resources for this research project. FS acknowledges the Australian Research Council, grant no. DP 160100959, and GEJ acknowledges the University of Melbourne for hosting a sabbatical visit. Access to the NMR spectrometers was supported through collaboration with the Bio21 Institute, Melbourne University, Australia. HGM acknowledges the National Research Foundation of South Africa (grant no. 109204).